Small integral membrane protein 43 (SMIM43)
Homo sapiens — UniProt Q4W5P6
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 43 (SMIM43) is a protein from Homo sapiens identified by UniProt accession Q4W5P6, 63 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q4W5P6; gene symbol SMIM43.
- Organism: Homo sapiens.
- Length: 63 amino acids.
- Top disease associations (Open Targets): platelet-to-lymphocyte ratio, body weight and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 43 |
|---|---|
| UniProt accession | Q4W5P6 |
| Gene | SMIM43 |
| Organism | Homo sapiens |
| Length | 63 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- platelet-to-lymphocyte ratio · score 0.18
- body weight · score 0.10
- mean corpuscular volume · score 0.09
- type 2 diabetes mellitus · score 0.07
- erythrocyte count · score 0.06
- hip circumference · score 0.06
- BMI-adjusted hip circumference · score 0.05
- glioblastoma multiforme · score 0.05
- fat body mass · score 0.05
- mean corpuscular hemoglobin · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4W5P6-F1 | alphafold | PREDICTED | 76.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4W5P6.
Amino-acid sequence (63 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM43?
The strongest Open Targets associations for SMIM43 are platelet-to-lymphocyte ratio, body weight, mean corpuscular volume, type 2 diabetes mellitus and erythrocyte count.
How long is the SMIM43 protein?
The Homo sapiens SMIM43 protein (UniProt Q4W5P6) is 63 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4W5P6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4W5P6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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