Spermatogenesis-associated protein 45 (SPATA45)
Homo sapiens — UniProt Q537H7
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 45 (SPATA45) is a protein from Homo sapiens identified by UniProt accession Q537H7, 98 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q537H7; gene symbol SPATA45.
- Organism: Homo sapiens.
- Length: 98 amino acids.
- Top disease associations (Open Targets): eosinophil count, platelet count and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 45 |
|---|---|
| UniProt accession | Q537H7 |
| Gene | SPATA45 |
| Organism | Homo sapiens |
| Length | 98 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.13
- platelet count · score 0.10
- eosinophil percentage of leukocytes · score 0.08
- reticulocyte count · score 0.07
- childhood onset asthma · score 0.05
- hemoglobin measurement · score 0.05
- type 1 diabetes mellitus · score 0.05
- reticulocyte measurement · score 0.05
- drug use measurement · score 0.04
- mathematical ability · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q537H7-F1 | alphafold | PREDICTED | 64.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q537H7.
Amino-acid sequence (98 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA45?
The strongest Open Targets associations for SPATA45 are eosinophil count, platelet count, eosinophil percentage of leukocytes, reticulocyte count and childhood onset asthma.
How long is the SPATA45 protein?
The Homo sapiens SPATA45 protein (UniProt Q537H7) is 98 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q537H7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q537H7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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