Centrosomal protein of 55 kDa (CEP55)
Homo sapiens — UniProt Q53EZ4
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein of 55 kDa (CEP55) is a protein from Homo sapiens identified by UniProt accession Q53EZ4, 464 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.
- UniProt accession: Q53EZ4; gene symbol CEP55.
- Organism: Homo sapiens.
- Length: 464 amino acids.
- Top disease associations (Open Targets): multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome, genetic disorder and Abnormality of prenatal development or birth.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein of 55 kDa |
|---|---|
| UniProt accession | Q53EZ4 |
| Gene | CEP55 |
| Organism | Homo sapiens |
| Length | 464 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (211)
Diseases linked to this target (Open Targets).
- multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome · score 0.72
- genetic disorder · score 0.47
- Abnormality of prenatal development or birth · score 0.27
- renal dysplasia · score 0.19
- neurodegenerative disease · score 0.18
- high density lipoprotein cholesterol measurement · score 0.17
- encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 · score 0.12
- Lethal encephalopathy due to mitochondrial and peroxisomal fission defect · score 0.12
- neoplasm · score 0.11
- cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q53EZ4-F1 | alphafold | PREDICTED | 82.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q53EZ4.
Amino-acid sequence (464 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP55?
The strongest Open Targets associations for CEP55 are multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome, genetic disorder, Abnormality of prenatal development or birth, renal dysplasia and neurodegenerative disease.
How long is the CEP55 protein?
The Homo sapiens CEP55 protein (UniProt Q53EZ4) is 464 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q53EZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q53EZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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