Protein unc-50 homolog (UNC50)
Homo sapiens — UniProt Q53HI1
Data last refreshed: (UniProt release unknown)
Key facts
Protein unc-50 homolog (UNC50) is a protein from Homo sapiens identified by UniProt accession Q53HI1, 259 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q53HI1; gene symbol UNC50.
- Organism: Homo sapiens.
- Length: 259 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, arthrogryposis multiplex congenita and fetal akinesia deformation sequence.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein unc-50 homolog |
|---|---|
| UniProt accession | Q53HI1 |
| Gene | UNC50 |
| Organism | Homo sapiens |
| Length | 259 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- arthrogryposis multiplex congenita · score 0.12
- fetal akinesia deformation sequence · score 0.12
- fetal akinesia deformation sequence 1 · score 0.12
- creatinine measurement · score 0.09
- neoplasm · score 0.08
- neuritic plaque measurement · score 0.07
- hepatocellular carcinoma · score 0.06
- cancer · score 0.04
- arthrogryposis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q53HI1-F1 | alphafold | PREDICTED | 88.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q53HI1.
Amino-acid sequence (259 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC50?
The strongest Open Targets associations for UNC50 are neurodegenerative disease, arthrogryposis multiplex congenita, fetal akinesia deformation sequence, fetal akinesia deformation sequence 1 and creatinine measurement.
How long is the UNC50 protein?
The Homo sapiens UNC50 protein (UniProt Q53HI1) is 259 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q53HI1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q53HI1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.