Spindlin-4 (SPIN4)
Homo sapiens — UniProt Q56A73
Data last refreshed: (UniProt release unknown)
Key facts
Spindlin-4 (SPIN4) is a protein from Homo sapiens identified by UniProt accession Q56A73, 249 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q56A73; gene symbol SPIN4.
- Organism: Homo sapiens.
- Length: 249 amino acids.
- Top disease associations (Open Targets): Lui-Jee-Baron syndrome, type 2 diabetes mellitus and MODY.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spindlin-4 |
|---|---|
| UniProt accession | Q56A73 |
| Gene | SPIN4 |
| Organism | Homo sapiens |
| Length | 249 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- Lui-Jee-Baron syndrome · score 0.45
- type 2 diabetes mellitus · score 0.13
- MODY · score 0.08
- diabetes mellitus · score 0.07
- obesity · score 0.07
- Obesity · score 0.07
- dysplasia epiphysealis hemimelica · score 0.07
- metabolic syndrome X · score 0.06
- Sertoli Cell-Only Syndrome · score 0.06
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q56A73-F1 | alphafold | PREDICTED | 81.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q56A73.
Amino-acid sequence (249 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIN4?
The strongest Open Targets associations for SPIN4 are Lui-Jee-Baron syndrome, type 2 diabetes mellitus, MODY, diabetes mellitus and obesity.
How long is the SPIN4 protein?
The Homo sapiens SPIN4 protein (UniProt Q56A73) is 249 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q56A73 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q56A73 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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