Serine/threonine-protein kinase TNNI3K (TNNI3K)
Homo sapiens — UniProt Q59H18
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase TNNI3K (TNNI3K) is a protein from Homo sapiens identified by UniProt accession Q59H18, 835 residues long. MolForge cross-references it against 10 known binders and 112 disease associations.
- UniProt accession: Q59H18; gene symbol TNNI3K.
- Organism: Homo sapiens.
- Length: 835 amino acids.
- Top disease associations (Open Targets): atrial conduction disease, neurodegenerative disease and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase TNNI3K |
|---|---|
| UniProt accession | Q59H18 |
| Gene | TNNI3K |
| Organism | Homo sapiens |
| Length | 835 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- atrial conduction disease · score 0.71
- neurodegenerative disease · score 0.33
- self reported educational attainment · score 0.31
- PHF-tau measurement · score 0.28
- Arrhythmogenic right ventricular dysplasia · score 0.28
- parental longevity · score 0.27
- genetic disorder · score 0.19
- dilated cardiomyopathy · score 0.18
- body mass index · score 0.18
- insomnia measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q59H18-F1 | alphafold | PREDICTED | 79.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q59H18.
Amino-acid sequence (835 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNNI3K?
The strongest Open Targets associations for TNNI3K are atrial conduction disease, neurodegenerative disease, self reported educational attainment, PHF-tau measurement and Arrhythmogenic right ventricular dysplasia.
How long is the TNNI3K protein?
The Homo sapiens TNNI3K protein (UniProt Q59H18) is 835 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q59H18 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q59H18 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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