Shadow of prion protein (SPRN)

About Shadow of prion protein

Shadow of prion protein (SPRN) is a protein from Homo sapiens identified by UniProt accession Q5BIV9, 151 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Shadow of prion protein
UniProt accession	Q5BIV9
Gene	SPRN
Organism	Homo sapiens
Length	151 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

DNA methylation · score 0.24
MODY · score 0.07
Obesity · score 0.06
obesity · score 0.06
prion disease · score 0.06
Sertoli Cell-Only Syndrome · score 0.06
metabolic syndrome X · score 0.05
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1 · score 0.04
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2 · score 0.04
body mass index · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5BIV9-F1	alphafold	PREDICTED	53.78	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5BIV9.

Amino-acid sequence (151 residues)

MNWAPATCWA LLLAAAFLCD SGAAKGGRGG ARGSARGGVR GGARGASRVR VRPAQRYGAP GSSLRVAAAG AAAGAAAGAA AGLAAGSGWR RAAGPGERGL EDEEDGVPGG NGTGPGIYSY RAWTSGAGPT RGPRLCLVLG GALGALGLLR P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards