Coiled-coil domain-containing protein 178 (CCDC178)
Homo sapiens — UniProt Q5BJE1
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 178 (CCDC178) is a protein from Homo sapiens identified by UniProt accession Q5BJE1, 867 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.
- UniProt accession: Q5BJE1; gene symbol CCDC178.
- Organism: Homo sapiens.
- Length: 867 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and Epiretinal membrane.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 178 |
|---|---|
| UniProt accession | Q5BJE1 |
| Gene | CCDC178 |
| Organism | Homo sapiens |
| Length | 867 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- ulcerative colitis · score 0.31
- Epiretinal membrane · score 0.30
- lean body mass · score 0.19
- X-linked corneal dermoid · score 0.08
- X-linked endothelial corneal dystrophy · score 0.08
- Fuchs endothelial corneal dystrophy · score 0.08
- autosomal dominant keratitis · score 0.07
- base metabolic rate measurement · score 0.07
- Lisch epithelial corneal dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5BJE1-F1 | alphafold | PREDICTED | 76.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5BJE1.
Amino-acid sequence (867 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC178?
The strongest Open Targets associations for CCDC178 are neurodegenerative disease, ulcerative colitis, Epiretinal membrane, lean body mass and X-linked corneal dermoid.
How long is the CCDC178 protein?
The Homo sapiens CCDC178 protein (UniProt Q5BJE1) is 867 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5BJE1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5BJE1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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