Polyamine-transporter SLC45A4 (SLC45A4)
Homo sapiens — UniProt Q5BKX6
Data last refreshed: (UniProt release unknown)
Key facts
Polyamine-transporter SLC45A4 (SLC45A4) is a protein from Homo sapiens identified by UniProt accession Q5BKX6, 768 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q5BKX6; gene symbol SLC45A4.
- Organism: Homo sapiens.
- Length: 768 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): reticulocyte count, neutrophil count and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyamine-transporter SLC45A4 |
|---|---|
| UniProt accession | Q5BKX6 |
| Gene | SLC45A4 |
| Organism | Homo sapiens |
| Length | 768 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.48
- neutrophil count · score 0.48
- leukocyte count · score 0.48
- Immature Reticulocyte Fraction Measurement · score 0.46
- platelet count · score 0.46
- mean platelet volume · score 0.46
- reticulocyte measurement · score 0.46
- lymphocyte count · score 0.45
- platelet crit · score 0.45
- birth weight · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5BKX6-F1 | alphafold | PREDICTED | 65.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5BKX6.
Amino-acid sequence (768 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC45A4?
The strongest Open Targets associations for SLC45A4 are reticulocyte count, neutrophil count, leukocyte count, Immature Reticulocyte Fraction Measurement and platelet count.
How long is the SLC45A4 protein?
The Homo sapiens SLC45A4 protein (UniProt Q5BKX6) is 768 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5BKX6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5BKX6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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