Fibrous sheath-interacting protein 2 (FSIP2)
Homo sapiens — UniProt Q5CZC0
Gene: FSIP2Homo sapiensSwissProt reviewed
Data last refreshed: (UniProt release unknown)
Key facts
Fibrous sheath-interacting protein 2 (FSIP2) is a protein from Homo sapiens identified by UniProt accession Q5CZC0, 6907 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q5CZC0; gene symbol FSIP2.
- Organism: Homo sapiens.
- Length: 6907 amino acids.
- Top disease associations (Open Targets): azoospermia, non-syndromic male infertility due to sperm motility disorder and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fibrous sheath-interacting protein 2 |
|---|---|
| UniProt accession | Q5CZC0 |
| Gene | FSIP2 |
| Organism | Homo sapiens |
| Length | 6907 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.63
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- self reported educational attainment · score 0.28
- cognitive function measurement · score 0.25
- chronotype measurement · score 0.24
- intelligence · score 0.19
- atrial fibrillation · score 0.19
- PHF-tau measurement · score 0.19
- protein measurement · score 0.17
- male infertility with teratozoospermia due to single gene mutation · score 0.09
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5CZC0-F21 | alphafold | PREDICTED | 64.39 | — |
| AF-Q5CZC0-F20 | alphafold | PREDICTED | 61.25 | — |
| AF-Q5CZC0-F22 | alphafold | PREDICTED | 59.27 | — |
| AF-Q5CZC0-F18 | alphafold | PREDICTED | 58.60 | — |
| AF-Q5CZC0-F19 | alphafold | PREDICTED | 58.19 | — |
| AF-Q5CZC0-F24 | alphafold | PREDICTED | 57.14 | — |
| AF-Q5CZC0-F23 | alphafold | PREDICTED | 56.49 | — |
| AF-Q5CZC0-F27 | alphafold | PREDICTED | 55.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5CZC0.
Amino-acid sequence (6907 residues)
MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD LPLGVKLPVI PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL HDPHLKAYYK RKDILKRLKK GGYITSNNKV VCTLRELNKY RQYLTSLKLD FERNYIKEQR ILAKQLHNIP ENNQIPQHCD VAQVQNWLLK EGTESIKDQE RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH TRRKLTLRRK IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG DQNTYKETHG HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD GMVSKNSSIF DDRGGINISG QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK ETNADWDGRP TKRSSYLCES GPQAHATDPG IFSSPVYTNM QQNLLQNCLQ EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN NTYPVSDDSI LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL ASFETGTKKS KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL KGETEVILES ILREIMSDLT QAIPSLSSVT AEVFVEQCER EKEILLSNAH IPSVASEIVE NMLEKLESAV EKKCVEMFSQ DLSVDIKPSL AASDELLTSS NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN EFLHLKDTNK LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV NESFQKSRQP RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY SDDENEEIDN IVKNVLDSTF KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK PPTKPGSRSK AAFHDWELKT EPPSTNHEDI LKKKLSSNKD ISTFSQDQKH QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL VSEKPQGLSH QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK SEPKPVDDIN DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN IVLCAIQNEL ELHKENLNLR EIDHTKSLTD KGFFANTDKK LESLVTSIDD DILASPLLTC IYDMLLSSEN AHQRSISLSS RKPKSATDSV DVQSILPNRQ DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL HEMLSKLLGT HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK EETKSKAKPV APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH LEILGAINDG NKKSNKIGWE YESTNISRDT HEASFLSALY MHAKKVSSAI LKVIQTELNV TSSDLKTSVE NPPPETQILK YVVKLILDAV SSDMFNEMES EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE RSPQREEVKT RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV FHKLYSAAMT ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT FQSRFSVADK ETKVNLAEDI VQAILTNLET FATSKVKSLF YSQVNFTVPV ALPIQQDHST LSKALSAKDS YSDEQFSCCS VDHTKSGKTN LCQLSLSKLN TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ IVNALLDIIS RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS DVILISNDIV NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ PLKGSKTERK TERFSYSRNQ KSAYADDNQI TVVEKEDTQK SATDSCEENA NFITKTIFKR LESFATERID SLITLAFQSK EKSFVIPELE NCKQNDSIFY DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST IHLSQARLKT YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE QNQMILENKR QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE VTGHLPPLNE TANFISNSKI KTSDTTQKNS FQSHINSVAN DIVESVLGKM YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK PLRFRETKQA GKISNSPRYA ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI TNFVSLPLKV SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI VKEFGKVKQT KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR LSQGNIGTGS LPKQQACFYL ENVSSQLEHI FPREGIFKKL FDKWQTESND KENEKCKLLM IAENVLTEIS IKAKELEYSL SLLNLPPLEN CESRFYNHFK GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD SEETLSNSKE HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS DKSESNTINF KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE ISQMEPSSIS ILKENIVASE IIGTLMDQCT YFNESLIQNL SRESLFQGAE NAYTVNQVEL ATNMKMFTSK LKEGSLGINP SQVSKTGFVF CSDEDMKEKY RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK VQDHRPRESN FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN ENREIMKPFF ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL EASREDSSFL QKLKKKEYPK IETVKEVEAF TFADHEMGSN EVHLIARHVT TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY ESKQFLRNIY DDSSIYQCCE HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS IHSQVFESRS ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR QASPRDWQFS TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF NIVSDLFSPD ECLDTGMDSG KIQRTYFYSS NNEQPNSILT NNLQLSSKSV FLLNVVCEKL IRILLEECTS TAFPDKGSVS EETSAEECQL LKMLQSVEDG KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML TIISHSLVKS LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK EMDKVAIHNK LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV SWLNEMNTLF VNNVVNEFNN AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV YYDVLQQYEL KVACGNNPVY DNASIAEQIT NGILLEILDY KLPSCFKEHL IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH SFLEDVIRRL LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI IQEIIENHLQ PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP LDIHLDSFVR EIVARLLSKI FSPKHNTEIE LKNMTQRIVN SINRHFNKAK IHILYDDKEQ AFFSFNTDIV DELATSVYRN ALKQHGLDLA VDKESEDSGI FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV QDILSNISKS TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN VVQTSGSQES AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS SDTYFDDERR QLFYTSVYSS TFLEDVISGV LRKIFHRVVG IVQTKSIRDS EDELFEKAEE LIHLITGEFS KAQVSIIDNT EERLCLPPVE RDVVKTIVDM VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD FQIHPDLIAN LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK KQSMISAKDI QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII KEIFNHHIQS FLSEDKTLLL AAVDQTYKLK AIDPKQRELS FIVNSSVFLE EVISELLCKI LYAFSHNMLV TENPDRVKLK LTRIVTTLVN SIVLEFTTSE ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI QIHRVIQSDT ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF VEAASKLTDE IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK TSEFQAEVQK DADKKGCSFL SKLAGFIMKE IMYHHLQPFL HGEESSFSDL SDYDHVSELA KSGKEKTQPS LYSATFLEDI IIDLVHKFCS LLIITEDSKK NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF PPIDKETVDK ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS STPDCKNMMS TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK SGMINLTSGL ATGVTNKKEV DENKVGICTQ KHSENVSKVT STTTVKSKDT QEPNLSETFN NNEIEKKRNL IPTDKKGKDD EIYTHFSLII DDTEYEKEVL GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT TTDTLEIRIR TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE EREKEKVREE IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF SSIPETQIQD RCQNVSDKQN QAKLYDTAMK LINSLLKEFS DAQIKVFRPD KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS SIKIKSADKM PPMHKMMRKP SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS NGENLARRLT SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FSIP2?
The strongest Open Targets associations for FSIP2 are azoospermia, non-syndromic male infertility due to sperm motility disorder, self reported educational attainment, cognitive function measurement and chronotype measurement.
How long is the FSIP2 protein?
The Homo sapiens FSIP2 protein (UniProt Q5CZC0) is 6907 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5CZC0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5CZC0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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