Cancer/testis antigen family 45 member A2 (CT45A2)
Homo sapiens — UniProt Q5DJT8
Data last refreshed: (UniProt release unknown)
Key facts
Cancer/testis antigen family 45 member A2 (CT45A2) is a protein from Homo sapiens identified by UniProt accession Q5DJT8, 189 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q5DJT8; gene symbol CT45A2.
- Organism: Homo sapiens.
- Length: 189 amino acids.
- Top disease associations (Open Targets): hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency and thyroid hormone metabolism, abnormal, 2.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cancer/testis antigen family 45 member A2 |
|---|---|
| UniProt accession | Q5DJT8 |
| Gene | CT45A2 |
| Organism | Homo sapiens |
| Length | 189 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- hypertriglyceridemia 2 · score 0.08
- cholesterol-ester transfer protein deficiency · score 0.08
- thyroid hormone metabolism, abnormal, 2 · score 0.07
- sitosterolemia · score 0.07
- Combined hyperlipidemia · score 0.06
- homozygous familial hypercholesterolemia · score 0.06
- hypercholesterolemia, autosomal dominant, 3 · score 0.05
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.05
- hypercholesterolemia, autosomal dominant, type B · score 0.05
- pancreatic triacylglycerol lipase deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5DJT8-F1 | alphafold | PREDICTED | 67.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5DJT8.
Amino-acid sequence (189 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CT45A2?
The strongest Open Targets associations for CT45A2 are hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency, thyroid hormone metabolism, abnormal, 2, sitosterolemia and Combined hyperlipidemia.
How long is the CT45A2 protein?
The Homo sapiens CT45A2 protein (UniProt Q5DJT8) is 189 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5DJT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5DJT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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