Serine protease inhibitor Kazal-type 9 (SPINK9)
Homo sapiens — UniProt Q5DT21
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 9 (SPINK9) is a protein from Homo sapiens identified by UniProt accession Q5DT21, 86 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q5DT21; gene symbol SPINK9.
- Organism: Homo sapiens.
- Length: 86 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pulse pressure measurement and prostate adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 9 |
|---|---|
| UniProt accession | Q5DT21 |
| Gene | SPINK9 |
| Organism | Homo sapiens |
| Length | 86 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- pulse pressure measurement · score 0.22
- prostate adenocarcinoma · score 0.21
- thyroid gland adenocarcinoma · score 0.19
- clear cell renal carcinoma · score 0.18
- neutrophil count · score 0.18
- leukocyte count · score 0.18
- gastric adenocarcinoma · score 0.16
- mean corpuscular volume · score 0.14
- endometrial cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5DT21-F1 | alphafold | PREDICTED | 91.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5DT21.
Amino-acid sequence (86 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK9?
The strongest Open Targets associations for SPINK9 are neurodegenerative disease, pulse pressure measurement, prostate adenocarcinoma, thyroid gland adenocarcinoma and clear cell renal carcinoma.
How long is the SPINK9 protein?
The Homo sapiens SPINK9 protein (UniProt Q5DT21) is 86 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5DT21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5DT21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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