DnaJ homolog subfamily C member 21 (DNAJC21)
Homo sapiens — UniProt Q5F1R6
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily C member 21 (DNAJC21) is a protein from Homo sapiens identified by UniProt accession Q5F1R6, 531 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.
- UniProt accession: Q5F1R6; gene symbol DNAJC21.
- Organism: Homo sapiens.
- Length: 531 amino acids.
- Top disease associations (Open Targets): autosomal dominant aplasia and myelodysplasia, Pancytopenia and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily C member 21 |
|---|---|
| UniProt accession | Q5F1R6 |
| Gene | DNAJC21 |
| Organism | Homo sapiens |
| Length | 531 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- autosomal dominant aplasia and myelodysplasia · score 0.69
- Pancytopenia · score 0.55
- neurodegenerative disease · score 0.50
- Shwachman-Diamond syndrome · score 0.45
- genetic disorder · score 0.41
- Abnormality of the tongue · score 0.34
- Webbed neck · score 0.34
- acute myeloid leukemia · score 0.34
- Short stature · score 0.34
- Pectus excavatum · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5F1R6-F1 | alphafold | PREDICTED | 71.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5F1R6.
Amino-acid sequence (531 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJC21?
The strongest Open Targets associations for DNAJC21 are autosomal dominant aplasia and myelodysplasia, Pancytopenia, neurodegenerative disease, Shwachman-Diamond syndrome and genetic disorder.
How long is the DNAJC21 protein?
The Homo sapiens DNAJC21 protein (UniProt Q5F1R6) is 531 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5F1R6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5F1R6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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