Arylsulfatase H (ARSH)
Homo sapiens — UniProt Q5FYA8
Data last refreshed: (UniProt release unknown)
Key facts
Arylsulfatase H (ARSH) is a protein from Homo sapiens identified by UniProt accession Q5FYA8, 562 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q5FYA8; gene symbol ARSH.
- Organism: Homo sapiens.
- Length: 562 amino acids.
- Top disease associations (Open Targets): Multiple sulfatase deficiency, mucosulfatidosis and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arylsulfatase H |
|---|---|
| UniProt accession | Q5FYA8 |
| Gene | ARSH |
| Organism | Homo sapiens |
| Length | 562 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- Multiple sulfatase deficiency · score 0.05
- mucosulfatidosis · score 0.05
- neoplasm · score 0.05
- non-small cell lung carcinoma · score 0.03
- chronic obstructive pulmonary disease · score 0.02
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.01
- breast cancer · score 0.01
- hepatocellular carcinoma · score 0.01
- leiomyoma · score 0.01
- recessive X-linked ichthyosis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5FYA8-F1 | alphafold | PREDICTED | 94.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5FYA8.
Amino-acid sequence (562 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARSH?
The strongest Open Targets associations for ARSH are Multiple sulfatase deficiency, mucosulfatidosis, neoplasm, non-small cell lung carcinoma and chronic obstructive pulmonary disease.
How long is the ARSH protein?
The Homo sapiens ARSH protein (UniProt Q5FYA8) is 562 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5FYA8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5FYA8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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