Arylsulfatase I (ARSI)
Homo sapiens — UniProt Q5FYB1
Data last refreshed: (UniProt release unknown)
Key facts
Arylsulfatase I (ARSI) is a protein from Homo sapiens identified by UniProt accession Q5FYB1, 569 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q5FYB1; gene symbol ARSI.
- Organism: Homo sapiens.
- Length: 569 amino acids.
- Top disease associations (Open Targets): autosomal recessive spastic paraplegia type 66, Spastic paraplegia and hereditary spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arylsulfatase I |
|---|---|
| UniProt accession | Q5FYB1 |
| Gene | ARSI |
| Organism | Homo sapiens |
| Length | 569 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- autosomal recessive spastic paraplegia type 66 · score 0.37
- Spastic paraplegia · score 0.19
- hereditary spastic paraplegia · score 0.15
- body height · score 0.13
- cancer · score 0.06
- metastatic melanoma · score 0.05
- neoplasm · score 0.04
- metabolite measurement · score 0.03
- adult T-cell leukemia/lymphoma · score 0.02
- head and neck squamous cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5FYB1-F1 | alphafold | PREDICTED | 87.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5FYB1.
Amino-acid sequence (569 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARSI?
The strongest Open Targets associations for ARSI are autosomal recessive spastic paraplegia type 66, Spastic paraplegia, hereditary spastic paraplegia, body height and cancer.
How long is the ARSI protein?
The Homo sapiens ARSI protein (UniProt Q5FYB1) is 569 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5FYB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5FYB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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