GPI ethanolamine phosphate transferase 2, catalytic subunit (PIGG)
Homo sapiens — UniProt Q5H8A4
Data last refreshed: (UniProt release unknown)
Key facts
GPI ethanolamine phosphate transferase 2, catalytic subunit (PIGG) is a protein from Homo sapiens identified by UniProt accession Q5H8A4, 983 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q5H8A4; gene symbol PIGG.
- Organism: Homo sapiens.
- Length: 983 amino acids.
- Top disease associations (Open Targets): intellectual disability, autosomal recessive 53, autosomal recessive non-syndromic intellectual disability and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI ethanolamine phosphate transferase 2, catalytic subunit |
|---|---|
| UniProt accession | Q5H8A4 |
| Gene | PIGG |
| Organism | Homo sapiens |
| Length | 983 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal recessive 53 · score 0.82
- autosomal recessive non-syndromic intellectual disability · score 0.57
- genetic disorder · score 0.49
- hyperphosphatasia-intellectual disability syndrome · score 0.34
- Seizure · score 0.27
- neurodegenerative disease · score 0.22
- infection · score 0.04
- infect · score 0.04
- sex hormone-binding globulin measurement · score 0.02
- pharyngitis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5H8A4-F1 | alphafold | PREDICTED | 83.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5H8A4.
Amino-acid sequence (983 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGG?
The strongest Open Targets associations for PIGG are intellectual disability, autosomal recessive 53, autosomal recessive non-syndromic intellectual disability, genetic disorder, hyperphosphatasia-intellectual disability syndrome and Seizure.
How long is the PIGG protein?
The Homo sapiens PIGG protein (UniProt Q5H8A4) is 983 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5H8A4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5H8A4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.