Armadillo repeat-containing X-linked protein 4 (ARMCX4)

Homo sapiens — UniProt Q5H9R4

Gene: ARMCX4Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Armadillo repeat-containing X-linked protein 4 (ARMCX4) is a protein from Homo sapiens identified by UniProt accession Q5H9R4, 2290 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

UniProt accession: Q5H9R4; gene symbol ARMCX4.
Organism: Homo sapiens.
Length: 2290 amino acids.
Top disease associations (Open Targets): osteoarthritis, knee, endometrial carcinoma and breast carcinoma.
3D structure: AlphaFold model available.

Target properties

Protein name	Armadillo repeat-containing X-linked protein 4
UniProt accession	Q5H9R4
Gene	ARMCX4
Organism	Homo sapiens
Length	2290 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

osteoarthritis, knee · score 0.08
endometrial carcinoma · score 0.01
breast carcinoma · score 0.01
acute quadriplegic myopathy · score 0.01
cancer · score 0.01
male infertility · score 0.01
juvenile dermatomyositis · score 0.01
stomach neoplasm · score 0.00
Parkinson disease · score 0.00
myelodysplastic syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5H9R4-F1	alphafold	PREDICTED	40.46	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5H9R4.

Amino-acid sequence (2290 residues)

MGRIQEVGWV TAGLVIWAGT CYYIYKFTKG RAQSVRTLAR NGSTVKMETV VGVQSQTLAI NEAEIKTKPQ VEIGAETGAR SGPRAEVETK ATAIAIHRAN SQAKAMVGAE PETQSESKVV AGTLVMTEAV TLTEVKAKAR EVAMKEAVTQ TDAEAGKIVK KEAVTQTKAK AWALVAKTEA KREAMTQTKA ETHILAEKET EINRVMVTQS ETLAVPREVA KMGATNKTGI VDETKTRALE ETVSVAKTQS EARPGATVDA RGNPNGMSRE VAGVDMKSCA QSQAVTKIQG DDMPGTGVED MGNCKTMSRA ESGADTRASA QPQIFAKTQT EAIPGAKIDA GGNTNAMCKV GAGADVRACI QPQTVAKKQA EVTSGARVDG RGNTNVISKA ITGADMRAAA QPQAVASTHA EAMSDAKVKN RGNPNAMTKA GAKANLRANS QVEALPDARD KSRGNPNVMA KVGDGTDMLS CTQPQLVASV QADTLSDGKI KVRGNVNTMP KEGAGVDMKA QGMAQSQGEA LPNTRGKARG KAKAKCKTGP GMDMKTCTQP QAGVKTPAEA LLDSRVDGRG NPNATSKAGT KADQRVCGQP LVVANPQGEA LPGAKNKVKG NPHTVLKVGA GEGTTDSAQP EAVVSFQGEA LLGTKNKVKG NPNVVLKAEV GEGAMGTAQL QIMASSKGEA LLDSKNKVKG NSNAVSKAGA GTDTTGSVQP QIVANSQGEV LPGAKNKIRG NPTTVPNSGV GPYTTDSARL QAVANSQGEV LPGAKNKVKA NLNAVSKAEA GMGATGSVQP QAVANSHCET LPGAKNKVRG NWNAVSKAGA GMDTRGSAQP QAVANSQGEV LPGAKNKVKG NPNVVSKAGA REDTVGSTQP QVLASSQRET LPGARNKVKG NSNVVSKAGA REDTMGSAQP QVVANSQRET LPGARNKVKG NSNAISKAEA GAGIMGSVQV QVVASFQGEV LPGAKNKVRG NSNAVPKAEA GADTVGSAQP QAVANSQSET LLGARNKVKG NTIAVPKAGT GAGTRHSAQP QIVAGSQGET LPGARDKSMS TSEAEATAED EAYAKPEAEA MPTSESEGGS GTQACRKTQP NIHDYYWNGI GVEDWIAAER WIKFRFQTMD GDWENSVSWA DDENEASIGS WSGASDKAGI IRSWAVACDE TSVKSWAGAR AENVVGIGTW ARAGEQASGG LWAGGQTSEG TWAGDKASGG AWTGAENQAS GGSWALAGNQ AIGELWAAGQ ASDGSWPGGQ ASGVSWVGEE AIGGSWTGAE NQASEGSWAG AGAGNMSSVS YWAGVVDQAG GGSWAGTSDQ SGGGSKPRFE DQASGEGSWA GAGGQASGGS MLGPEDQSSG RSWADTADQA SGGSRLGHVD QSSGGAWAGT LDQSGGGSKP RFENQTTEEG SWAGAGGQAG GGSKVGPEDQ SSGRSWANSG DQISGGFLVG IVDQANGGSW TGAGHPASVG PKPIFEDQVS GRGSWADARE QVVGDSRLGL RDQSSGDSWA GTGDQASGWF CVCPGSQTNG GSWGGASGQD VGGSRPGPTN QSSAGSWDSP GSQVSGSCWT GAGAVDQAGG CSKPGFEDQA IGGGFWPGAG DQTGGGSRPG SEDQSSGIGS WGVAGGQVLG GARPGPADQS SGGSWAGTGN QSSGRSWIGP GDQAVDCSKP EFEDQACGGG SWAGAGSQAS GESWAGSRPG NEAIGGSRMG SEDQATGGSW ARSEDQASGR FQVSFEVEAN EGFWFGPGAE AVIGSWCWTE EKADIVSRPD DKDEATTASR SGAGEEAMIC SRIEAENKAS SGSWIRSEEV AYMGSCVGAE AGAGAEAGAG AEAGAGAGAE AGAEAGAGAG AGPGTESGAG IWSWDGDATT VESRLGAGEE AGVESWTLAR NVGEDELSRE SSPDIEEISL RSLFWAESEN SNTFRSKSGK DASFESGAGD NTSIKDKFEA AGGVDIGSWF CAGNENTSED KSAPKAKAKK SSESRGIYPY MVPGAGMGSW DGAMIWSETK FAHQSEASFP VEDESRKQTR TGEKTRPWSC RCKHEANMDP RDLEKLICMI EMTEDPSVHE IANNALYNSA DYSYSHEVVR NVGGISVIES LLNNPYPSVR QKALNALNNI SVAAENHRKV KTYLNQVCED TVTYPLNSNV QLAGLRLIRH LTITSEYQHM VTNYISEFLR LLTVGSGETK DHVLGMLLNF SKNPSMTKDL LIANAPTSLI NIFSKKETKE NILNALSLFE NINYHFKRRA KAFTQDKFSK NSLYFLFQRP KACAKKLRAL AAECNDPEVK ERVELLISKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with ARMCX4?

The strongest Open Targets associations for ARMCX4 are osteoarthritis, knee, endometrial carcinoma, breast carcinoma, acute quadriplegic myopathy and cancer.

How long is the ARMCX4 protein?

The Homo sapiens ARMCX4 protein (UniProt Q5H9R4) is 2290 amino acids long.

Browse: Targets: A · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5H9R4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5H9R4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.