Serine/threonine-protein phosphatase 6 regulatory…

About Serine/threonine-protein phosphatase 6 regulatory subunit 3

Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) is a protein from Homo sapiens identified by UniProt accession Q5H9R7, 873 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Serine/threonine-protein phosphatase 6 regulatory subunit 3
UniProt accession	Q5H9R7
Gene	PPP6R3
Organism	Homo sapiens
Length	873 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

bone quantitative ultrasound measurement · score 0.38
bone density · score 0.36
heel bone mineral density · score 0.32
Red cell distribution width · score 0.30
mathematical ability · score 0.29
self reported educational attainment · score 0.29
mean corpuscular volume · score 0.28
mean corpuscular hemoglobin concentration · score 0.26
osteoporosis · score 0.26
lean body mass · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5H9R7-F1	alphafold	PREDICTED	67.36	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5H9R7.

Amino-acid sequence (873 residues)

MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS SLQQAFSDYQ MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP SSSPEQRTGQ PSAPGDTSVN GPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3)