DDB1- and CUL4-associated factor 17 (DCAF17)
Homo sapiens — UniProt Q5H9S7
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 17 (DCAF17) is a protein from Homo sapiens identified by UniProt accession Q5H9S7, 520 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.
- UniProt accession: Q5H9S7; gene symbol DCAF17.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): Woodhouse-Sakati syndrome, Dystonia and neurodegeneration with brain iron accumulation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 17 |
|---|---|
| UniProt accession | Q5H9S7 |
| Gene | DCAF17 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (142)
Diseases linked to this target (Open Targets).
- Woodhouse-Sakati syndrome · score 0.78
- Dystonia · score 0.46
- neurodegeneration with brain iron accumulation · score 0.41
- neurodegenerative disease · score 0.26
- FEV/FVC ratio · score 0.21
- genetic disorder · score 0.19
- BMI-adjusted hip circumference · score 0.16
- azoospermia · score 0.10
- body height · score 0.09
- mean platelet volume · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5H9S7-F1 | alphafold | PREDICTED | 87.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5H9S7.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF17?
The strongest Open Targets associations for DCAF17 are Woodhouse-Sakati syndrome, Dystonia, neurodegeneration with brain iron accumulation, neurodegenerative disease and FEV/FVC ratio.
How long is the DCAF17 protein?
The Homo sapiens DCAF17 protein (UniProt Q5H9S7) is 520 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5H9S7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5H9S7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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