Meckelin (TMEM67)
Homo sapiens — UniProt Q5HYA8
Data last refreshed: (UniProt release unknown)
Key facts
Meckelin (TMEM67) is a protein from Homo sapiens identified by UniProt accession Q5HYA8, 995 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.
- UniProt accession: Q5HYA8; gene symbol TMEM67.
- Organism: Homo sapiens.
- Length: 995 amino acids.
- Top disease associations (Open Targets): Joubert syndrome with hepatic defect, Meckel syndrome, type 3 and Joubert syndrome 6.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Meckelin |
|---|---|
| UniProt accession | Q5HYA8 |
| Gene | TMEM67 |
| Organism | Homo sapiens |
| Length | 995 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (164)
Diseases linked to this target (Open Targets).
- Joubert syndrome with hepatic defect · score 0.86
- Meckel syndrome, type 3 · score 0.82
- Joubert syndrome 6 · score 0.81
- nephronophthisis 11 · score 0.80
- Meckel syndrome · score 0.75
- Joubert syndrome · score 0.73
- Bardet-Biedl syndrome 14 · score 0.72
- RHYNS syndrome · score 0.68
- Senior-Boichis syndrome · score 0.62
- Joubert syndrome and related disorders · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYA8-F1 | alphafold | PREDICTED | 84.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYA8.
Amino-acid sequence (995 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM67?
The strongest Open Targets associations for TMEM67 are Joubert syndrome with hepatic defect, Meckel syndrome, type 3, Joubert syndrome 6, nephronophthisis 11 and Meckel syndrome.
How long is the TMEM67 protein?
The Homo sapiens TMEM67 protein (UniProt Q5HYA8) is 995 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYA8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYA8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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