Trans-2,3-enoyl-CoA reductase-like (TECRL)
Homo sapiens — UniProt Q5HYJ1
Data last refreshed: (UniProt release unknown)
Key facts
Trans-2,3-enoyl-CoA reductase-like (TECRL) is a protein from Homo sapiens identified by UniProt accession Q5HYJ1, 363 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q5HYJ1; gene symbol TECRL.
- Organism: Homo sapiens.
- Length: 363 amino acids.
- Top disease associations (Open Targets): catecholaminergic polymorphic ventricular tachycardia, Abnormality of the cardiovascular system and Dementia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trans-2,3-enoyl-CoA reductase-like |
|---|---|
| UniProt accession | Q5HYJ1 |
| Gene | TECRL |
| Organism | Homo sapiens |
| Length | 363 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- catecholaminergic polymorphic ventricular tachycardia · score 0.66
- Abnormality of the cardiovascular system · score 0.54
- Dementia · score 0.31
- Alzheimer disease · score 0.31
- cellulitis · score 0.30
- Prolonged QT interval · score 0.27
- self reported educational attainment · score 0.24
- body mass index · score 0.17
- brain measurement · score 0.13
- body height · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYJ1-F1 | alphafold | PREDICTED | 84.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYJ1.
Amino-acid sequence (363 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TECRL?
The strongest Open Targets associations for TECRL are catecholaminergic polymorphic ventricular tachycardia, Abnormality of the cardiovascular system, Dementia, Alzheimer disease and cellulitis.
How long is the TECRL protein?
The Homo sapiens TECRL protein (UniProt Q5HYJ1) is 363 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYJ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYJ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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