2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5)
Homo sapiens — UniProt Q5HYK3
Data last refreshed: (UniProt release unknown)
Key facts
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) is a protein from Homo sapiens identified by UniProt accession Q5HYK3, 327 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q5HYK3; gene symbol COQ5.
- Organism: Homo sapiens.
- Length: 327 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, coenzyme q10 deficiency, primary, 9 and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial |
|---|---|
| UniProt accession | Q5HYK3 |
| Gene | COQ5 |
| Organism | Homo sapiens |
| Length | 327 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- coenzyme q10 deficiency, primary, 9 · score 0.51
- lysosomal storage disease · score 0.31
- multiple sclerosis · score 0.31
- Parkinson disease · score 0.31
- Alzheimer disease · score 0.31
- reticulocyte count · score 0.24
- sex hormone-binding globulin measurement · score 0.21
- reticulocyte measurement · score 0.20
- osteoarthritis, knee · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYK3-F1 | alphafold | PREDICTED | 82.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYK3.
Amino-acid sequence (327 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COQ5?
The strongest Open Targets associations for COQ5 are neurodegenerative disease, coenzyme q10 deficiency, primary, 9, lysosomal storage disease, multiple sclerosis and Parkinson disease.
How long is the COQ5 protein?
The Homo sapiens COQ5 protein (UniProt Q5HYK3) is 327 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYK3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYK3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.