Transmembrane protein 196 (TMEM196)
Homo sapiens — UniProt Q5HYL7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 196 (TMEM196) is a protein from Homo sapiens identified by UniProt accession Q5HYL7, 178 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q5HYL7; gene symbol TMEM196.
- Organism: Homo sapiens.
- Length: 178 amino acids.
- Top disease associations (Open Targets): body mass index, triglyceride measurement and response to selective serotonin reuptake inhibitor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 196 |
|---|---|
| UniProt accession | Q5HYL7 |
| Gene | TMEM196 |
| Organism | Homo sapiens |
| Length | 178 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- body mass index · score 0.41
- triglyceride measurement · score 0.22
- response to selective serotonin reuptake inhibitor · score 0.22
- body height · score 0.20
- cortical surface area measurement · score 0.16
- heel bone mineral density · score 0.15
- BMI-adjusted waist circumference · score 0.15
- neuroimaging measurement · score 0.15
- brain measurement · score 0.15
- cortical thickness · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYL7-F1 | alphafold | PREDICTED | 78.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYL7.
Amino-acid sequence (178 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM196?
The strongest Open Targets associations for TMEM196 are body mass index, triglyceride measurement, response to selective serotonin reuptake inhibitor, body height and cortical surface area measurement.
How long is the TMEM196 protein?
The Homo sapiens TMEM196 protein (UniProt Q5HYL7) is 178 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYL7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYL7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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