Probable ribonuclease ZC3H12B (ZC3H12B)
Homo sapiens — UniProt Q5HYM0
Data last refreshed: (UniProt release unknown)
Key facts
Probable ribonuclease ZC3H12B (ZC3H12B) is a protein from Homo sapiens identified by UniProt accession Q5HYM0, 836 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q5HYM0; gene symbol ZC3H12B.
- Organism: Homo sapiens.
- Length: 836 amino acids.
- Top disease associations (Open Targets): Intellectual disability-developmental delay-contractures syndrome, testosterone measurement and Monoamine oxidase A deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ribonuclease ZC3H12B |
|---|---|
| UniProt accession | Q5HYM0 |
| Gene | ZC3H12B |
| Organism | Homo sapiens |
| Length | 836 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- Intellectual disability-developmental delay-contractures syndrome · score 0.34
- testosterone measurement · score 0.19
- Monoamine oxidase A deficiency · score 0.06
- hemoglobin D disease · score 0.05
- 46,XY complete gonadal dysgenesis · score 0.04
- dominant beta-thalassemia · score 0.04
- hemoglobin E disease · score 0.04
- hemoglobin C-beta-thalassemia syndrome · score 0.04
- hemoglobin H disease · score 0.04
- Testicular regression syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYM0-F1 | alphafold | PREDICTED | 58.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYM0.
Amino-acid sequence (836 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZC3H12B?
The strongest Open Targets associations for ZC3H12B are Intellectual disability-developmental delay-contractures syndrome, testosterone measurement, Monoamine oxidase A deficiency, hemoglobin D disease and 46,XY complete gonadal dysgenesis.
How long is the ZC3H12B protein?
The Homo sapiens ZC3H12B protein (UniProt Q5HYM0) is 836 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYM0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYM0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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