NHS-like protein 2 (NHSL2)
Homo sapiens — UniProt Q5HYW2
Data last refreshed: (UniProt release unknown)
Key facts
NHS-like protein 2 (NHSL2) is a protein from Homo sapiens identified by UniProt accession Q5HYW2, 1225 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q5HYW2; gene symbol NHSL2.
- Organism: Homo sapiens.
- Length: 1225 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia type 1, glycoprotein storage disease and immunodeficiency 75.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NHS-like protein 2 |
|---|---|
| UniProt accession | Q5HYW2 |
| Gene | NHSL2 |
| Organism | Homo sapiens |
| Length | 1225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 1 · score 0.11
- glycoprotein storage disease · score 0.03
- immunodeficiency 75 · score 0.03
- hemoglobin H disease · score 0.03
- dominant beta-thalassemia · score 0.03
- hemoglobin C-beta-thalassemia syndrome · score 0.03
- autoinflammation with episodic fever and lymphadenopathy · score 0.03
- combined immunodeficiency due to OX40 deficiency · score 0.03
- Hyperlipoproteinemia type 1 · score 0.03
- congenital nonspherocytic hemolytic anemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5HYW2-F1 | alphafold | PREDICTED | 47.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5HYW2.
Amino-acid sequence (1225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NHSL2?
The strongest Open Targets associations for NHSL2 are spinocerebellar ataxia type 1, glycoprotein storage disease, immunodeficiency 75, hemoglobin H disease and dominant beta-thalassemia.
How long is the NHSL2 protein?
The Homo sapiens NHSL2 protein (UniProt Q5HYW2) is 1225 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5HYW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5HYW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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