Putative malate dehydrogenase 1B (MDH1B)
Homo sapiens — UniProt Q5I0G3
Data last refreshed: (UniProt release unknown)
Key facts
Putative malate dehydrogenase 1B (MDH1B) is a protein from Homo sapiens identified by UniProt accession Q5I0G3, 518 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q5I0G3; gene symbol MDH1B.
- Organism: Homo sapiens.
- Length: 518 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, neurodegenerative disease and total blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative malate dehydrogenase 1B |
|---|---|
| UniProt accession | Q5I0G3 |
| Gene | MDH1B |
| Organism | Homo sapiens |
| Length | 518 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.21
- neurodegenerative disease · score 0.21
- total blood protein measurement · score 0.14
- insomnia · score 0.14
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- retinitis pigmentosa · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5I0G3-F1 | alphafold | PREDICTED | 86.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5I0G3.
Amino-acid sequence (518 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MDH1B?
The strongest Open Targets associations for MDH1B are self reported educational attainment, neurodegenerative disease, total blood protein measurement, insomnia and age-related macular degeneration.
How long is the MDH1B protein?
The Homo sapiens MDH1B protein (UniProt Q5I0G3) is 518 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5I0G3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5I0G3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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