Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase B (ALG10B)
Homo sapiens — UniProt Q5I7T1
Data last refreshed: (UniProt release unknown)
Key facts
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase B (ALG10B) is a protein from Homo sapiens identified by UniProt accession Q5I7T1, 473 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q5I7T1; gene symbol ALG10B.
- Organism: Homo sapiens.
- Length: 473 amino acids.
- Top disease associations (Open Targets): chronotype measurement, vitamin D measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase B |
|---|---|
| UniProt accession | Q5I7T1 |
| Gene | ALG10B |
| Organism | Homo sapiens |
| Length | 473 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.40
- vitamin D measurement · score 0.40
- type 2 diabetes mellitus · score 0.30
- hip bone size · score 0.27
- IGF-1 measurement · score 0.26
- lifestyle measurement · score 0.26
- circadian rhythm · score 0.25
- BMI-adjusted waist-hip ratio · score 0.24
- heart rate response to recovery post exercise · score 0.23
- hip bone mineral density · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5I7T1-F1 | alphafold | PREDICTED | 93.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5I7T1.
Amino-acid sequence (473 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALG10B?
The strongest Open Targets associations for ALG10B are chronotype measurement, vitamin D measurement, type 2 diabetes mellitus, hip bone size and IGF-1 measurement.
How long is the ALG10B protein?
The Homo sapiens ALG10B protein (UniProt Q5I7T1) is 473 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5I7T1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5I7T1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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