Beta-defensin 121 (DEFB121)
Homo sapiens — UniProt Q5J5C9
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 121 (DEFB121) is a protein from Homo sapiens identified by UniProt accession Q5J5C9, 76 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q5J5C9; gene symbol DEFB121.
- Organism: Homo sapiens.
- Length: 76 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, lung adenocarcinoma and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 121 |
|---|---|
| UniProt accession | Q5J5C9 |
| Gene | DEFB121 |
| Organism | Homo sapiens |
| Length | 76 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.32
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
- head and neck squamous cell carcinoma · score 0.15
- gastric adenocarcinoma · score 0.14
- gastric carcinoma · score 0.13
- Autosomal dominant striatal neurodegeneration · score 0.04
- monocyte count · score 0.04
- TPE interval measurement · score 0.03
- adolescent idiopathic scoliosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5J5C9-F1 | alphafold | PREDICTED | 84.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5J5C9.
Amino-acid sequence (76 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB121?
The strongest Open Targets associations for DEFB121 are alkaline phosphatase measurement, lung adenocarcinoma, cutaneous melanoma, head and neck squamous cell carcinoma and gastric adenocarcinoma.
How long is the DEFB121 protein?
The Homo sapiens DEFB121 protein (UniProt Q5J5C9) is 76 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5J5C9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5J5C9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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