ER membrane protein complex subunit 4 (EMC4)

About ER membrane protein complex subunit 4

ER membrane protein complex subunit 4 (EMC4) is a protein from Homo sapiens identified by UniProt accession Q5J8M3, 183 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	ER membrane protein complex subunit 4
UniProt accession	Q5J8M3
Gene	EMC4
Organism	Homo sapiens
Length	183 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.57
lysosomal storage disease · score 0.48
Alzheimer disease · score 0.38
Parkinson disease · score 0.38
multiple sclerosis · score 0.38
Corpus callosum agenesis - neuronopathy · score 0.17
agenesis of the corpus callosum with peripheral neuropathy · score 0.17
dengue disease · score 0.05
linear and whorled nevoid hypermelanosis · score 0.04
mean platelet volume · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5J8M3-F1	alphafold	PREDICTED	66.94	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5J8M3.

Amino-acid sequence (183 residues)

MTAQGGLVAN RGRRFKWAIE LSGPGGGSRG RSDRGSGQGD SLYPVGYLDK QVPDTSVQET DRILVEKRCW DIALGPLKQI PMNLFIMYMA GNTISIFPTM MVCMMAWRPI QALMAISATF KMLESSSQKF LQGLVYLIGN LMGLALAVYK CQSMGLLPTH ASDWLAFIEP PERMEFSGGG LLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards