Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EARS2)
Homo sapiens — UniProt Q5JPH6
Data last refreshed: (UniProt release unknown)
Key facts
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EARS2) is a protein from Homo sapiens identified by UniProt accession Q5JPH6, 523 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q5JPH6; gene symbol EARS2.
- Organism: Homo sapiens.
- Length: 523 amino acids.
- Top disease associations (Open Targets): Leukoencephalopathy - thalamus and brainstem anomalies - high lactate, leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial |
|---|---|
| UniProt accession | Q5JPH6 |
| Gene | EARS2 |
| Organism | Homo sapiens |
| Length | 523 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- Leukoencephalopathy - thalamus and brainstem anomalies - high lactate · score 0.82
- leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome · score 0.79
- genetic disorder · score 0.47
- Leigh syndrome · score 0.37
- epilepsy · score 0.37
- High palate · score 0.34
- Abnormal pinna morphology · score 0.34
- Global developmental delay · score 0.34
- Abnormal facial shape · score 0.34
- Seizure · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JPH6-F1 | alphafold | PREDICTED | 89.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JPH6.
Amino-acid sequence (523 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EARS2?
The strongest Open Targets associations for EARS2 are Leukoencephalopathy - thalamus and brainstem anomalies - high lactate, leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome, genetic disorder, Leigh syndrome and epilepsy.
How long is the EARS2 protein?
The Homo sapiens EARS2 protein (UniProt Q5JPH6) is 523 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JPH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JPH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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