A-kinase anchor protein 4 (AKAP4)
Homo sapiens — UniProt Q5JQC9
Data last refreshed: (UniProt release unknown)
Key facts
A-kinase anchor protein 4 (AKAP4) is a protein from Homo sapiens identified by UniProt accession Q5JQC9, 854 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q5JQC9; gene symbol AKAP4.
- Organism: Homo sapiens.
- Length: 854 amino acids.
- Top disease associations (Open Targets): non-syndromic male infertility due to sperm motility disorder, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A-kinase anchor protein 4 |
|---|---|
| UniProt accession | Q5JQC9 |
| Gene | AKAP4 |
| Organism | Homo sapiens |
| Length | 854 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- non-small cell lung carcinoma · score 0.09
- spermatogenic failure 45 · score 0.09
- spermatogenic failure 19 · score 0.09
- spermatogenic failure 43 · score 0.09
- spermatogenic failure 49 · score 0.09
- spermatogenic failure 18 · score 0.09
- spermatogenic failure 46 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JQC9-F1 | alphafold | PREDICTED | 53.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JQC9.
Amino-acid sequence (854 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AKAP4?
The strongest Open Targets associations for AKAP4 are non-syndromic male infertility due to sperm motility disorder, azoospermia, male infertility with teratozoospermia due to single gene mutation, non-small cell lung carcinoma and spermatogenic failure 45.
How long is the AKAP4 protein?
The Homo sapiens AKAP4 protein (UniProt Q5JQC9) is 854 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JQC9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JQC9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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