Germinal center-associated signaling and motility-like protein (GCSAML)
Homo sapiens — UniProt Q5JQS6
Data last refreshed: (UniProt release unknown)
Key facts
Germinal center-associated signaling and motility-like protein (GCSAML) is a protein from Homo sapiens identified by UniProt accession Q5JQS6, 135 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q5JQS6; gene symbol GCSAML.
- Organism: Homo sapiens.
- Length: 135 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Germinal center-associated signaling and motility-like protein |
|---|---|
| UniProt accession | Q5JQS6 |
| Gene | GCSAML |
| Organism | Homo sapiens |
| Length | 135 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- platelet count · score 0.34
- mean platelet volume · score 0.33
- platelet component distribution width · score 0.32
- platelet crit · score 0.31
- reticulocyte count · score 0.30
- urticaria · score 0.26
- neurodegenerative disease · score 0.25
- lymphocyte count · score 0.23
- mean corpuscular volume · score 0.23
- liver fibrosis measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JQS6-F1 | alphafold | PREDICTED | 65.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JQS6.
Amino-acid sequence (135 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GCSAML?
The strongest Open Targets associations for GCSAML are platelet count, mean platelet volume, platelet component distribution width, platelet crit and reticulocyte count.
How long is the GCSAML protein?
The Homo sapiens GCSAML protein (UniProt Q5JQS6) is 135 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JQS6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JQS6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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