Transmembrane protein 255A (TMEM255A)
Homo sapiens — UniProt Q5JRV8
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 255A (TMEM255A) is a protein from Homo sapiens identified by UniProt accession Q5JRV8, 349 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q5JRV8; gene symbol TMEM255A.
- Organism: Homo sapiens.
- Length: 349 amino acids.
- Top disease associations (Open Targets): Abnormal central motor function, major depressive disorder and obsessive-compulsive disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 255A |
|---|---|
| UniProt accession | Q5JRV8 |
| Gene | TMEM255A |
| Organism | Homo sapiens |
| Length | 349 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- Abnormal central motor function · score 0.10
- major depressive disorder · score 0.07
- obsessive-compulsive disorder · score 0.06
- Kidney Oncocytoma · score 0.05
- ovarian carcinoma · score 0.04
- breast carcinoma · score 0.03
- astrocytoma · score 0.03
- psoriasis · score 0.02
- Down syndrome · score 0.02
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JRV8-F1 | alphafold | PREDICTED | 65.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JRV8.
Amino-acid sequence (349 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM255A?
The strongest Open Targets associations for TMEM255A are Abnormal central motor function, major depressive disorder, obsessive-compulsive disorder, Kidney Oncocytoma and ovarian carcinoma.
How long is the TMEM255A protein?
The Homo sapiens TMEM255A protein (UniProt Q5JRV8) is 349 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JRV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JRV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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