Cytochrome c oxidase assembly factor 6 homolog (COA6)
Homo sapiens — UniProt Q5JTJ3
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly factor 6 homolog (COA6) is a protein from Homo sapiens identified by UniProt accession Q5JTJ3, 125 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q5JTJ3; gene symbol COA6.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): fatal infantile encephalocardiomyopathy, mitochondrial complex IV deficiency, nuclear type 22 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 6 homolog |
|---|---|
| UniProt accession | Q5JTJ3 |
| Gene | COA6 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- fatal infantile encephalocardiomyopathy · score 0.59
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.55
- neurodegenerative disease · score 0.53
- response to anticonvulsant · score 0.26
- genetic disorder · score 0.17
- diverticular disease · score 0.11
- diverticulitis · score 0.09
- lung adenocarcinoma · score 0.08
- congenital hydronephrosis · score 0.04
- kidney disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JTJ3-F1 | alphafold | PREDICTED | 77.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JTJ3.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COA6?
The strongest Open Targets associations for COA6 are fatal infantile encephalocardiomyopathy, mitochondrial complex IV deficiency, nuclear type 22, neurodegenerative disease, response to anticonvulsant and genetic disorder.
How long is the COA6 protein?
The Homo sapiens COA6 protein (UniProt Q5JTJ3) is 125 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JTJ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JTJ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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