Torsin-1A-interacting protein 1 (TOR1AIP1)
Homo sapiens — UniProt Q5JTV8
Data last refreshed: (UniProt release unknown)
Key facts
Torsin-1A-interacting protein 1 (TOR1AIP1) is a protein from Homo sapiens identified by UniProt accession Q5JTV8, 583 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q5JTV8; gene symbol TOR1AIP1.
- Organism: Homo sapiens.
- Length: 583 amino acids.
- Top disease associations (Open Targets): autosomal recessive limb-girdle muscular dystrophy type 2Y, neurodegenerative disease and Abnormality of refraction.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Torsin-1A-interacting protein 1 |
|---|---|
| UniProt accession | Q5JTV8 |
| Gene | TOR1AIP1 |
| Organism | Homo sapiens |
| Length | 583 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2Y · score 0.76
- neurodegenerative disease · score 0.52
- Abnormality of refraction · score 0.27
- prostate carcinoma · score 0.22
- genetic disorder · score 0.19
- cystatin C measurement · score 0.10
- melanoma · score 0.07
- neoplasm · score 0.06
- mean corpuscular volume · score 0.06
- pyknoachondrogenesis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JTV8-F1 | alphafold | PREDICTED | 61.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JTV8.
Amino-acid sequence (583 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOR1AIP1?
The strongest Open Targets associations for TOR1AIP1 are autosomal recessive limb-girdle muscular dystrophy type 2Y, neurodegenerative disease, Abnormality of refraction, prostate carcinoma and genetic disorder.
How long is the TOR1AIP1 protein?
The Homo sapiens TOR1AIP1 protein (UniProt Q5JTV8) is 583 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JTV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JTV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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