Centrosomal protein of 78 kDa (CEP78)
Homo sapiens — UniProt Q5JTW2
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein of 78 kDa (CEP78) is a protein from Homo sapiens identified by UniProt accession Q5JTW2, 689 residues long. MolForge cross-references it against 0 known binders and 190 disease associations.
- UniProt accession: Q5JTW2; gene symbol CEP78.
- Organism: Homo sapiens.
- Length: 689 amino acids.
- Top disease associations (Open Targets): cone-rod dystrophy and hearing loss, Cone rod dystrophy and cone-rod dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein of 78 kDa |
|---|---|
| UniProt accession | Q5JTW2 |
| Gene | CEP78 |
| Organism | Homo sapiens |
| Length | 689 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (190)
Diseases linked to this target (Open Targets).
- cone-rod dystrophy and hearing loss · score 0.75
- Cone rod dystrophy · score 0.63
- cone-rod dystrophy · score 0.48
- sensorineural hearing loss · score 0.42
- Sensorineural hearing impairment · score 0.42
- Retinal dystrophy · score 0.40
- Usher syndrome type 3 · score 0.37
- low grade glioma · score 0.23
- breast adenocarcinoma · score 0.23
- hemoglobin measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JTW2-F1 | alphafold | PREDICTED | 64.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JTW2.
Amino-acid sequence (689 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP78?
The strongest Open Targets associations for CEP78 are cone-rod dystrophy and hearing loss, Cone rod dystrophy, cone-rod dystrophy, sensorineural hearing loss and Sensorineural hearing impairment.
How long is the CEP78 protein?
The Homo sapiens CEP78 protein (UniProt Q5JTW2) is 689 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JTW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JTW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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