Alanine--tRNA ligase, mitochondrial (AARS2)
Homo sapiens — UniProt Q5JTZ9
Data last refreshed: (UniProt release unknown)
Key facts
Alanine--tRNA ligase, mitochondrial (AARS2) is a protein from Homo sapiens identified by UniProt accession Q5JTZ9, 985 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q5JTZ9; gene symbol AARS2.
- Organism: Homo sapiens.
- Length: 985 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation defect type 8, leukoencephalopathy, progressive, with ovarian failure and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alanine--tRNA ligase, mitochondrial |
|---|---|
| UniProt accession | Q5JTZ9 |
| Gene | AARS2 |
| Organism | Homo sapiens |
| Length | 985 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 8 · score 0.77
- leukoencephalopathy, progressive, with ovarian failure · score 0.74
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.50
- Pulmonary hypoplasia · score 0.41
- cardiomyopathy · score 0.37
- Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia · score 0.37
- mitochondrial disease · score 0.37
- hydrops fetalis · score 0.37
- ovarioleukodystrophy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JTZ9-F1 | alphafold | PREDICTED | 87.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JTZ9.
Amino-acid sequence (985 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AARS2?
The strongest Open Targets associations for AARS2 are combined oxidative phosphorylation defect type 8, leukoencephalopathy, progressive, with ovarian failure, neurodegenerative disease, genetic disorder and Pulmonary hypoplasia.
How long is the AARS2 protein?
The Homo sapiens AARS2 protein (UniProt Q5JTZ9) is 985 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JTZ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JTZ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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