Dynein regulatory complex subunit 5 (DRC5)
Homo sapiens — UniProt Q5JU00
Data last refreshed: (UniProt release unknown)
Key facts
Dynein regulatory complex subunit 5 (DRC5) is a protein from Homo sapiens identified by UniProt accession Q5JU00, 501 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q5JU00; gene symbol DRC5.
- Organism: Homo sapiens.
- Length: 501 amino acids.
- Top disease associations (Open Targets): rheumatoid arthritis, neurodegenerative disease and Immunosuppressant use measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein regulatory complex subunit 5 |
|---|---|
| UniProt accession | Q5JU00 |
| Gene | DRC5 |
| Organism | Homo sapiens |
| Length | 501 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.26
- neurodegenerative disease · score 0.26
- Immunosuppressant use measurement · score 0.18
- drug use measurement · score 0.11
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
- spermatogenic failure 49 · score 0.08
- spermatogenic failure 43 · score 0.08
- spermatogenic failure 45 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JU00-F1 | alphafold | PREDICTED | 82.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JU00.
Amino-acid sequence (501 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DRC5?
The strongest Open Targets associations for DRC5 are rheumatoid arthritis, neurodegenerative disease, Immunosuppressant use measurement, drug use measurement and azoospermia.
How long is the DRC5 protein?
The Homo sapiens DRC5 protein (UniProt Q5JU00) is 501 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JU00 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JU00 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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