Cilia- and flagella-associated protein 157 (CFAP157)
Homo sapiens — UniProt Q5JU67
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 157 (CFAP157) is a protein from Homo sapiens identified by UniProt accession Q5JU67, 520 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q5JU67; gene symbol CFAP157.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, serum metabolite measurement and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 157 |
|---|---|
| UniProt accession | Q5JU67 |
| Gene | CFAP157 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.15
- serum metabolite measurement · score 0.14
- mathematical ability · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 72 · score 0.08
- spermatogenic failure 46 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 27 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JU67-F1 | alphafold | PREDICTED | 78.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JU67.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP157?
The strongest Open Targets associations for CFAP157 are self reported educational attainment, serum metabolite measurement, mathematical ability, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the CFAP157 protein?
The Homo sapiens CFAP157 protein (UniProt Q5JU67) is 520 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JU67 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JU67 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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