Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1)
Homo sapiens — UniProt Q5JUK2
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) is a protein from Homo sapiens identified by UniProt accession Q5JUK2, 328 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q5JUK2; gene symbol SOHLH1.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): azoospermia, 46,XX gonadal dysgenesis and primary ovarian insufficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 |
|---|---|
| UniProt accession | Q5JUK2 |
| Gene | SOHLH1 |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.62
- 46,XX gonadal dysgenesis · score 0.55
- primary ovarian insufficiency · score 0.39
- neurodegenerative disease · score 0.32
- genetic non-acquired premature ovarian failure · score 0.26
- breast ductal adenocarcinoma · score 0.11
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- 46,XX testicular disorder of sex development · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JUK2-F1 | alphafold | PREDICTED | 57.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JUK2.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOHLH1?
The strongest Open Targets associations for SOHLH1 are azoospermia, 46,XX gonadal dysgenesis, primary ovarian insufficiency, neurodegenerative disease and genetic non-acquired premature ovarian failure.
How long is the SOHLH1 protein?
The Homo sapiens SOHLH1 protein (UniProt Q5JUK2) is 328 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JUK2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JUK2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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