Potassium channel subfamily T member 1 (KCNT1)
Homo sapiens — UniProt Q5JUK3
Data last refreshed: (UniProt release unknown)
Key facts
Potassium channel subfamily T member 1 (KCNT1) is a protein from Homo sapiens identified by UniProt accession Q5JUK3, 1230 residues long. MolForge cross-references it against 4 known binders and 144 disease associations.
- UniProt accession: Q5JUK3; gene symbol KCNT1.
- Organism: Homo sapiens.
- Length: 1230 amino acids.
- Approved drugs acting on it (DrugCentral): Niclosamide and Loxapine.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, 14, autosomal dominant nocturnal frontal lobe epilepsy 5 and malignant migrating partial seizures of infancy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium channel subfamily T member 1 |
|---|---|
| UniProt accession | Q5JUK3 |
| Gene | KCNT1 |
| Organism | Homo sapiens |
| Length | 1230 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (144)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 14 · score 0.82
- autosomal dominant nocturnal frontal lobe epilepsy 5 · score 0.76
- malignant migrating partial seizures of infancy · score 0.68
- autosomal dominant nocturnal frontal lobe epilepsy · score 0.67
- developmental and epileptic encephalopathy · score 0.58
- Seizure · score 0.51
- genetic disorder · score 0.50
- childhood-onset epilepsy syndrome · score 0.37
- Rolandic epilepsy · score 0.34
- epilepsy syndrome · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JUK3-F1 | alphafold | PREDICTED | 73.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JUK3.
Amino-acid sequence (1230 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target KCNT1?
DrugCentral lists 2 approved drugs whose mechanism of action is KCNT1: Niclosamide and Loxapine.
Which diseases are associated with KCNT1?
The strongest Open Targets associations for KCNT1 are developmental and epileptic encephalopathy, 14, autosomal dominant nocturnal frontal lobe epilepsy 5, malignant migrating partial seizures of infancy, autosomal dominant nocturnal frontal lobe epilepsy and developmental and epileptic encephalopathy.
How long is the KCNT1 protein?
The Homo sapiens KCNT1 protein (UniProt Q5JUK3) is 1230 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JUK3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JUK3 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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