KRAB domain-containing protein 4 (KRABD4)
Homo sapiens — UniProt Q5JUW0
Data last refreshed: (UniProt release unknown)
Key facts
KRAB domain-containing protein 4 (KRABD4) is a protein from Homo sapiens identified by UniProt accession Q5JUW0, 171 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q5JUW0; gene symbol KRABD4.
- Organism: Homo sapiens.
- Length: 171 amino acids.
- Top disease associations (Open Targets): mental or behavioural disorder, non-syndromic X-linked intellectual disability and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KRAB domain-containing protein 4 |
|---|---|
| UniProt accession | Q5JUW0 |
| Gene | KRABD4 |
| Organism | Homo sapiens |
| Length | 171 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- mental or behavioural disorder · score 0.02
- non-syndromic X-linked intellectual disability · score 0.01
- psoriasis · score 0.01
- Pick disease · score 0.00
- Intellectual disability · score 0.00
- Cognitive impairment · score 0.00
- schizophrenia · score 0.00
- ermine phenotype · score 0.00
- major depressive disorder · score 0.00
- Neurodevelopmental delay · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JUW0-F1 | alphafold | PREDICTED | 48.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JUW0.
Amino-acid sequence (171 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRABD4?
The strongest Open Targets associations for KRABD4 are mental or behavioural disorder, non-syndromic X-linked intellectual disability, psoriasis, Pick disease and Intellectual disability.
How long is the KRABD4 protein?
The Homo sapiens KRABD4 protein (UniProt Q5JUW0) is 171 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JUW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JUW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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