Spindlin-3 (SPIN3)
Homo sapiens — UniProt Q5JUX0
Data last refreshed: (UniProt release unknown)
Key facts
Spindlin-3 (SPIN3) is a protein from Homo sapiens identified by UniProt accession Q5JUX0, 258 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q5JUX0; gene symbol SPIN3.
- Organism: Homo sapiens.
- Length: 258 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spindlin-3 |
|---|---|
| UniProt accession | Q5JUX0 |
| Gene | SPIN3 |
| Organism | Homo sapiens |
| Length | 258 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- neoplasm · score 0.04
- testosterone measurement · score 0.02
- balding measurement · score 0.02
- hypertension · score 0.02
- Sepsis · score 0.01
- cancer · score 0.01
- esophageal squamous cell carcinoma · score 0.01
- infection · score 0.00
- infect · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JUX0-F1 | alphafold | PREDICTED | 80.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JUX0.
Amino-acid sequence (258 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIN3?
The strongest Open Targets associations for SPIN3 are neurodegenerative disease, neoplasm, testosterone measurement, balding measurement and hypertension.
How long is the SPIN3 protein?
The Homo sapiens SPIN3 protein (UniProt Q5JUX0) is 258 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JUX0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JUX0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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