EF-hand domain-containing protein 1 (EFHC1)
Homo sapiens — UniProt Q5JVL4
Data last refreshed: (UniProt release unknown)
Key facts
EF-hand domain-containing protein 1 (EFHC1) is a protein from Homo sapiens identified by UniProt accession Q5JVL4, 640 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: Q5JVL4; gene symbol EFHC1.
- Organism: Homo sapiens.
- Length: 640 amino acids.
- Top disease associations (Open Targets): juvenile myoclonic epilepsy, eosinophil count and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EF-hand domain-containing protein 1 |
|---|---|
| UniProt accession | Q5JVL4 |
| Gene | EFHC1 |
| Organism | Homo sapiens |
| Length | 640 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- juvenile myoclonic epilepsy · score 0.79
- eosinophil count · score 0.40
- mean platelet volume · score 0.40
- appendicular lean mass · score 0.40
- leukocyte count · score 0.40
- neutrophil count · score 0.40
- platelet count · score 0.39
- Generalized non-motor (absence) seizure · score 0.28
- platelet component distribution width · score 0.27
- atopic eczema · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JVL4-F1 | alphafold | PREDICTED | 83.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JVL4.
Amino-acid sequence (640 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EFHC1?
The strongest Open Targets associations for EFHC1 are juvenile myoclonic epilepsy, eosinophil count, mean platelet volume, appendicular lean mass and leukocyte count.
How long is the EFHC1 protein?
The Homo sapiens EFHC1 protein (UniProt Q5JVL4) is 640 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JVL4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JVL4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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