Calcium homeostasis modulator protein 4 (CALHM4)
Homo sapiens — UniProt Q5JW98
Data last refreshed: (UniProt release unknown)
Key facts
Calcium homeostasis modulator protein 4 (CALHM4) is a protein from Homo sapiens identified by UniProt accession Q5JW98, 314 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q5JW98; gene symbol CALHM4.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): Familial exudative vitreoretinopathy, proliferative vitreoretinopathy and exudative vitreoretinopathy 2, X-linked.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium homeostasis modulator protein 4 |
|---|---|
| UniProt accession | Q5JW98 |
| Gene | CALHM4 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- Familial exudative vitreoretinopathy · score 0.04
- proliferative vitreoretinopathy · score 0.04
- exudative vitreoretinopathy 2, X-linked · score 0.03
- sitting height measurement · score 0.02
- preeclampsia · score 0.01
- myxosarcoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JW98-F1 | alphafold | PREDICTED | 74.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JW98.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CALHM4?
The strongest Open Targets associations for CALHM4 are Familial exudative vitreoretinopathy, proliferative vitreoretinopathy, exudative vitreoretinopathy 2, X-linked, sitting height measurement and preeclampsia.
How long is the CALHM4 protein?
The Homo sapiens CALHM4 protein (UniProt Q5JW98) is 314 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JW98 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JW98 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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