Signal-regulatory protein beta-2 (SIRPB2)
Homo sapiens — UniProt Q5JXA9
Data last refreshed: (UniProt release unknown)
Key facts
Signal-regulatory protein beta-2 (SIRPB2) is a protein from Homo sapiens identified by UniProt accession Q5JXA9, 342 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q5JXA9; gene symbol SIRPB2.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Top disease associations (Open Targets): myeloperoxidase measurement, systemic lupus erythematosus and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal-regulatory protein beta-2 |
|---|---|
| UniProt accession | Q5JXA9 |
| Gene | SIRPB2 |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- myeloperoxidase measurement · score 0.31
- systemic lupus erythematosus · score 0.03
- blood protein measurement · score 0.03
- reticulocyte count · score 0.03
- platelet crit · score 0.02
- platelet count · score 0.02
- carotid artery intima media thickness · score 0.02
- Immature Reticulocyte Fraction Measurement · score 0.02
- glomerular filtration rate · score 0.02
- Tetralogy of Fallot · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JXA9-F1 | alphafold | PREDICTED | 76.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JXA9.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRPB2?
The strongest Open Targets associations for SIRPB2 are myeloperoxidase measurement, systemic lupus erythematosus, blood protein measurement, reticulocyte count and platelet crit.
How long is the SIRPB2 protein?
The Homo sapiens SIRPB2 protein (UniProt Q5JXA9) is 342 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JXA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JXA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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