G-protein coupled receptor-associated sorting protein 1 (GPRASP1)
Homo sapiens — UniProt Q5JY77
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor-associated sorting protein 1 (GPRASP1) is a protein from Homo sapiens identified by UniProt accession Q5JY77, 1395 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q5JY77; gene symbol GPRASP1.
- Organism: Homo sapiens.
- Length: 1395 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Intellectual disability and follicular thyroid carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor-associated sorting protein 1 |
|---|---|
| UniProt accession | Q5JY77 |
| Gene | GPRASP1 |
| Organism | Homo sapiens |
| Length | 1395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- Intellectual disability · score 0.16
- follicular thyroid carcinoma · score 0.07
- follicular thyroid adenoma · score 0.07
- cancer · score 0.05
- papillary carcinoma · score 0.03
- ovarian carcinoma · score 0.03
- neoplasm · score 0.03
- thyroid cancer · score 0.03
- undifferentiated carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JY77-F1 | alphafold | PREDICTED | 41.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JY77.
Amino-acid sequence (1395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPRASP1?
The strongest Open Targets associations for GPRASP1 are neurodegenerative disease, Intellectual disability, follicular thyroid carcinoma, follicular thyroid adenoma and cancer.
How long is the GPRASP1 protein?
The Homo sapiens GPRASP1 protein (UniProt Q5JY77) is 1395 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JY77 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JY77 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.