Ephrin type-A receptor 10 (EPHA10)
Homo sapiens — UniProt Q5JZY3
Data last refreshed: (UniProt release unknown)
Key facts
Ephrin type-A receptor 10 (EPHA10) is a protein from Homo sapiens identified by UniProt accession Q5JZY3, 1008 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.
- UniProt accession: Q5JZY3; gene symbol EPHA10.
- Organism: Homo sapiens.
- Length: 1008 amino acids.
- Top disease associations (Open Targets): medullary thyroid gland carcinoma, thyroid cancer and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ephrin type-A receptor 10 |
|---|---|
| UniProt accession | Q5JZY3 |
| Gene | EPHA10 |
| Organism | Homo sapiens |
| Length | 1008 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- medullary thyroid gland carcinoma · score 0.48
- thyroid cancer · score 0.47
- neoplasm · score 0.42
- thyroid carcinoma · score 0.39
- thyroid neoplasm · score 0.39
- non-small cell lung carcinoma · score 0.38
- nonsyndromic deafness · score 0.33
- autosomal dominant nonsyndromic hearing loss · score 0.33
- lung cancer · score 0.30
- eosinophil count · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5JZY3-F1 | alphafold | PREDICTED | 79.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5JZY3.
Amino-acid sequence (1008 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EPHA10?
The strongest Open Targets associations for EPHA10 are medullary thyroid gland carcinoma, thyroid cancer, neoplasm, thyroid carcinoma and thyroid neoplasm.
How long is the EPHA10 protein?
The Homo sapiens EPHA10 protein (UniProt Q5JZY3) is 1008 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5JZY3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5JZY3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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