Polyserase-2 (PRSS36)

About Polyserase-2

Polyserase-2 (PRSS36) is a protein from Homo sapiens identified by UniProt accession Q5K4E3, 855 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Polyserase-2
UniProt accession	Q5K4E3
Gene	PRSS36
Organism	Homo sapiens
Length	855 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

IGF-1 measurement · score 0.14
Red cell distribution width · score 0.07
smoking behaviour measurement · score 0.07
Alzheimer disease · score 0.06
family history of Alzheimer’s disease · score 0.06
deafness · score 0.06
brain measurement · score 0.05
benign adult familial myoclonic epilepsy · score 0.04
worry measurement · score 0.02
Sepsis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5K4E3-F1	alphafold	PREDICTED	78.63	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5K4E3.

Amino-acid sequence (855 residues)

MARHLLLPLV MLVISPIPGA FQDSALSPTQ EEPEDLDCGR PEPSARIVGG SNAQPGTWPW QVSLHHGGGH ICGGSLIAPS WVLSAAHCFM TNGTLEPAAE WSVLLGVHSQ DGPLDGAHTR AVAAIVVPAN YSQVELGADL ALLRLASPAS LGPAVWPVCL PRASHRFVHG TACWATGWGD VQEADPLPLP WVLQEVELRL LGEATCQCLY SQPGPFNLTL QILPGMLCAG YPEGRRDTCQ GDSGGPLVCE EGGRWFQAGI TSFGFGCGRR NRPGVFTAVA TYEAWIREQV MGSEPGPAFP TQPQKTQSDP QEPREENCTI ALPECGKAPR PGAWPWEAQV MVPGSRPCHG ALVSESWVLA PASCFLDPNS SDSPPRDLDA WRVLLPSRPR AERVARLVQH ENASWDNASD LALLQLRTPV NLSAASRPVC LPHPEHYFLP GSRCRLARWG RGEPALGPGA LLEAELLGGW WCHCLYGRQG AAVPLPGDPP HALCPAYQEK EEVGSCWNDS RWSLLCQEEG TWFLAGIRDF PSGCLRPRAF FPLQTHGPWI SHVTRGAYLE DQLAWDWGPD GEETETQTCP PHTEHGACGL RLEAAPVGVL WPWLAEVHVA GDRVCTGILL APGWVLAATH CVLRPGSTTV PYIEVYLGRA GASSLPQGHQ VSRLVISIRL PQHLGLRPPL ALLELSSRVE PSPSALPICL HPAGIPPGAS CWVLGWKEPQ DRVPVAAAVS ILTQRICDCL YQGILPPGTL CVLYAEGQEN RCEMTSAPPL LCQMTEGSWI LVGMAVQGSR ELFAAIGPEE AWISQTVGEA NFLPPSGSPH WPTGGSNLCP PELAKASGSP HAVYFLLLLT LLIQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards