Cyclin-dependent kinase-like 4 (CDKL4)
Homo sapiens — UniProt Q5MAI5
Data last refreshed: (UniProt release unknown)
Key facts
Cyclin-dependent kinase-like 4 (CDKL4) is a protein from Homo sapiens identified by UniProt accession Q5MAI5, 379 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q5MAI5; gene symbol CDKL4.
- Organism: Homo sapiens.
- Length: 379 amino acids.
- Top disease associations (Open Targets): total blood protein measurement, calcium measurement and early-onset non-syndromic cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cyclin-dependent kinase-like 4 |
|---|---|
| UniProt accession | Q5MAI5 |
| Gene | CDKL4 |
| Organism | Homo sapiens |
| Length | 379 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.08
- calcium measurement · score 0.07
- early-onset non-syndromic cataract · score 0.07
- Cataract-microcornea syndrome · score 0.06
- hereditary hyperferritinemia with congenital cataracts · score 0.06
- Total congenital cataract · score 0.06
- isolated ectopia lentis · score 0.06
- Cataract with Y-shaped suture opacities · score 0.05
- Anterior polar cataract · score 0.05
- Posterior polar cataract · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5MAI5-F1 | alphafold | PREDICTED | 79.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MAI5.
Amino-acid sequence (379 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDKL4?
The strongest Open Targets associations for CDKL4 are total blood protein measurement, calcium measurement, early-onset non-syndromic cataract, Cataract-microcornea syndrome and hereditary hyperferritinemia with congenital cataracts.
How long is the CDKL4 protein?
The Homo sapiens CDKL4 protein (UniProt Q5MAI5) is 379 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5MAI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5MAI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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